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The influence of ageing on the pharmacodynamics of sedative and anticonvulsant drugs in rats nov 24 2020 posted by j k rowling media publishing text id a925fe3b online pdf ebook epub library instituut voor verouderings en vaatziekten onderzoek tno instituut voor experimentele gerontologie tno date issued 1991 01 01 access open access references pharmacology. The influence of ageing on the pharmacodynamics of sedative and anticonvulsant drugs in rats. Objective sedative and anticonvulsant drugs which inhibit n methyl d aspartate receptor mediated excitation or enhance gaba mediated action may cause apoptotic neurodegeneration in the developing mammalian brain here we explored whether such agents influence early postnatal neurogenesis methods the n methyl d aspartate antagonist mk801 and the gaba subtype a agonists phenobarbital and . The age f1 28 051 and the interaction drug 9 age f1 28 071 did not have a significant effect on the locomotor activity discussion the results of this study have demonstrated a lack of age related differences in the sedative and anticonvulsant effects of zolpidem against ptz and picrotoxin induced seizures. The influence of ageing on the pharmacodynamics of sedative and anticonvulsant drugs in rats nov 15 2020 posted by clive cussler library text id a925fe3b online pdf ebook epub library sedative effect methods nine younger 24 to 28 years and nine elderly 67 to 81 years male volunteers received midazolam by a computer controlled device two infusion