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Advances in the diagnosis and management of well differentiated neuroendocrine neoplasms johannes hofland johannes hofland histology of a grade 2 neuroendocrine tumor net reveals a homogeneous population of neuroendocrine cells with slight atypia round to oval nuclei dense chromatin and moderate eosinophilic amphophilic cytoplasm . Advances in pulmonary neuroendocrine tumor management by kjell oberg the spectrum of neuroendocrine tumors nets of the lung include on the one hand typical carcinoids and atypical carcinoids with a more indolent behavior and on the other hand the highly aggressive poorly differentiated large and small cell carcinomas. Advances in the diagnosis and management of well differentiated and intermediate differentiated neuroendocrine tumors of the lung chest 2017 may15151141 1146 doi 101016 jchest201606018. Management treatment of gastroenteropancreatic neuroendocrine tumors review clinical trial outcomes future science group clin invest 2011 110 1457 table 1 the clinical presentations syndromes tumor types sites and hormones of gastroenteropancreatic